Expectation for "condition improvement" of skin aging

The five major factors leading to skin aging are said to be "photoaging", "oxidation", "dryness" "skin thinning" and " saccharification”. In order to preserve the youthful "skin condition", it is important to know these five major factors, and take countermeasures and good care of your skin every day.
So, the question is if we take measures against these five major factors, will we be able to stop skin aging?

The answer is "NO".

The fundamental cause of skin aging is "telomeres shortening of skin cells". The five major causes of skin aging are caused by the acceleration of "telomere shortening" in skin cells.

"defytime TAA First" is blended with high-class ingredients from the world and compounded with the latest Telomere Activating Molecule【TAM】, with the purpose to suppress this fundamental cause of “telomere shortening”, and it’s a high-class aging care cream that can expect "condition improvement" of skin aging.

"Aqua Oil Drops" contains the latest Telomerase Activating Molecule【TAM】and astaxanthin (antioxidant), which makes "the first" penetrate quicker into the skin.

☞ Recommended for pin point skin care!

  • I want to get rid of the wrinkles in the corner of my eyes.
  • I want to get rid of my wrinkles.
  • I want to tighten the sagging skin under my chin.
  • Recently, I am particularly concerned with my smile lines and I want to make it inconspicuous.
  • I want to get rid of age spots on my face.
  • I want to get rid of skin dullness and sagging skin.
  • I want to get rid of wrinkles on my forehead.
  • I have wrinkles between my eyebrows.
  • Cosmetic treatment/surgery is a little scary, and I was looking for something different.

《Product Feature 1》
Increasing penetration effect of "the First" a high-class aging care cream

Adding "Aqua Oil Drops" will make the high-class aging cream "the First" which is manufactured by Nano-emulsion method and turned into ultrafine particles penetrate the skin even more efficiently.

《Product Feature 2》
Measures against skin aging with "TAM" + "astaxanthin"

In addition to "Telomerase Activating Molecule (TAM)", which is a research result of Bill Andrews Ph.D., "Aqua Oil Drops" is compounded with "Astaxanthin", an antioxidant known for eliminating active oxygen that is said to be the primary cause of aging and diseases. Because "the first"
compounds "TAM" and "Aqua Oil Drops" compounds "TAM" and "astaxanthin", it can be expected to prevent skin oxidation and telomere shortening of skin cells, leading to improvement in skin.

defytime the First PREMIUM (Contents: Cream: 7.5g×2 / Oil drops: 25ml×1)
¥111,000(tax excluded)

How to Use

Let's target the areas on your skin for aging care.

The area to apply cream depends on which part you want to improve.

Everyone has different concerns when it comes to the skin. Skin condition changes depending on your age with concerns of wrinkles and skin firmness etc.
Please apply “defytime the First” on the parts where you have age spots, wrinkles, or sagging skin. Improvement of skin condition can be expected by TAM penetration effect.

Use twice a day in the morning and evening after cleansing your face

"defytime the First" is an aging care skin cream created for the purpose of targeting the parts you want to improve. In addition, it is even more effective if you use ultrasonic facial equipment’s or duma roller when applying the cream because it will penetrate deeper into the skin. Also combining it with "defytime TAA cream" is recommended.

Institute for Advanced Telomere Medicine recommendation

It is a product I would recommend for all women that are seeking beauty

As a plastic surgeon and as a cosmetic surgeon we do aging treatments for people with various skin types. I have used various cosmetics due to my job, and I would say that this product is excellent,
and the result of clinical verification is also remarkable. "the First PREMIUM" comes in a set including "the First" which adopts the latest Nano-emulsion manufacturing method and "Aqua Oil Drops" is compounded with TAM and antioxidant astaxanthin which suppresses cell aging.
Glowing clear skin gives people joy and it will also make you love your skin.
By all means, please let your skin awaken with "the First PREMIUM". 

Doctor / Toshie Matsumiya

Frequently Asked Questions

  1. Q1.What are the characteristics?
    Bill Andrews,Ph.D. pioneer of disease treatment by aging, combines "Telomerase Activating Molecule【TAM】 "which was born by many years of research, and aging care of the skin part of concern at pinpoint It becomes a cream.
  2. Q2.Wrinkles and spots, can you get sagging?
    Although there seems to be individual differences, reports from Italy's "Avici Research Laboratory" conducting various clinical trials such as overseas famous cosmetic manufacturers that the improvement of wrinkles, spots and sagging was confirmed in clinical trials I am receiving.
  3. Q3.How long do you use it?
    Please consider one month or more between Hari by moisture.
    Because the condition of your skin will change due to seasons and environmental influences, depending on the time it may take several months. We recommend you to continue using it.
  4. Q4.Is it okay to use it other than face and neck?
    "defytime the First" is a product made for the purpose of using for the face and neck which is particularly anxious, so there is no particular problem even if it is used for other parts.
  5. Q5.When should I apply?
    We recommend twice in the morning and thefternoon.
    There is no problem to use it in the order of "lotion" → "beauty essence" → "cream" after washing the face or in general
  6. Q6.How much should I apply on a single occasion?
    Regarding the amount to be applied, I think that it varies depending on the part to be applied, but as a guide, please apply as one push (about 0.5 g), familiar to the anxious part as a guide.
    In addition, if ultrasonic facial equipment and duma roller are used together, cream penetrates deeper, so it is effective.
  7. Q7.If you paint 'defytime the first', is it OK to paint other creams anymore?
    "defytime the First" is a mechanism that induces telomerase activity of cells by 【TAM】.
    It is more effective to use it together with the cosmetics you are currently using, or with "defytime TAA cream" etc.
  8. Q8.Sensitive skin, so worrying about side effects ...
    In the clinical trial at the Avici Laboratories, there were no reports of side effects, etc., but please be sure to conduct a patch test before use.
    Since this product contains more than 95% of natural ingredients, there is a possibility that ingredients that do not fit your skin are included rarely.
  9. Q9.Where I painted the cream, something like a red spot came out ...
    It seems that there are many cases in which it is familiar to your skin by using a small amount of application and using it every few days. Please try once. However, there seem to be cases where symptoms appear due to insufficient sleep, stress, vitamin deficiency etc, so please refrain from using it until your physical condition is recovered, for example when your physical condition is bad.
  10. Q10.How can I save it?
    Please keep away from direct sunlight and high temperature and humid place.
    Also, please follow the notes displayed on the product after opening, please use as soon as possible. Should you feel separation, deterioration, discoloration, odor, etc., please refrain from using it.
  11. Q11.Can I ship overseas?
    Fearfully, delivery is only in Japan, we do not ship to overseas, so please understand.
  12. Q12.Is there a sample?
    I'm sorry.
    We do not prepare samples at present.

About purchase

For purchase from outside Japan, please contact us.